Oestrogel is the same as Estrogel

Estrogel is made by Solvay Pharmaceuticcals. A product of the same type is made by Laboratoires Besins International of France.

Estrogel is a clear, odorless, hydro-alcoholic gel that provides for delivery of estradiol for estrogen replacement in a non-patch transdermal form.

Transdermal delivery of EstroGel will ensure the body receives a consistent and continuous supply of estrogen. Applied once daily on one arm from wrist to shoulder, Estrogel avoids first pass metabolism in the liver and minimizes application site skin irritation. The gel dries in as little as two to five minutes.

Clinical Trials

Data supporting the efficacy and tolerability of Estrogel in reducing the frequency and severity of moderate-to-severe vasomotor symptoms was demonstrated in a 12-week, double-blind, randomized, placebo-controlled, multicenter study. The study analyzed the effects of Estrogel on 145 healthy, postmenopausal women suffering from moderate-to-severe hot flashes.

Important Information

The use of unopposed estrogens in non-hysterectomized women increases the risk of endometrial cancer. Estrogens with or without progestins should not be used for the prevention of cardiovascular disease. The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. Other doses of conjugated estrogens with medroxyprogesterone and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials, and in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

Estrogens are contraindicated for patients with known or suspected pregnancy, breast cancer, active thrombophlebitis, or thromboembolic disorders.