Vaginal conjugated estrogens belongs to a class of hormones called estrogens. It is used for the treatment of vaginal dryness and genital shrinkage. They work by supplementing your system with the hormone that is no longer being produced by your body.

Unlike oral conjugated estrogens, it has not been determined whether vaginal conjugated estrogens increase your risk for endometrial cancer. However, the risk of endometrial cancer can be minimized for oral estrogens by taking a progestin at the same time.

FDA Approved Uses

Treatment of atrophic vaginitis and vulvar atrophy.

Contraindications

Any of the following may be reason to choose a different drug. Inform your doctor before starting therapy.

• Allergic to estrogens or cream components
• Known or suspected estrogen-dependent neoplasia
• Known or suspected pregnancy
• Undiagnosed abnormal genital bleeding
• Active thrombophlebitis or thromboembolic disorders

Dosage and Administration

Dosages may require modification to adjust for individual sensitivities and associated medical conditions.

Adults

0.3-1.25g of conjugated estrogens (equivalent of 0.5 to 2 g of cream) daily, intravaginally or topically, depending on the severity of the condition. Treatment should be cyclic (3 weeks on and 1 week off), and attempts to discontinue or taper the dose should be made at 3-6 month intervals.

Wash the applicator with warm water and soap after each use.