Progynon Depot is used to treat the symptoms of low estrogen in women who do not produce enough estrogen naturally. It is sometimes used to relieve the symptoms of certain types of prostate cancer.

Directions

The estradiol valerate form of long acting estrogen injection come as a liquid to inject into a muscle. Consult you doctor or health-care professional about frequency and correct dosage for your needs.

Special Precautions

Tell your doctor and pharmacist if you are allergic to estrogen injection, any other estrogen products, any other medications, or any of the ingredients in estrogen injection. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients in the brand of estrogen injection you plan to use.

Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); certain antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral);aprepitant (Emend); carbamazepine (Carbatrol, Epitol, Tegretol);cimetidine (Tagamet); clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); dexamethasone (Decadron, Dexpak); diltiazem (Cardizem, Dilacor, Tiazac, others); erythromycin (E.E.S, Erythrocin);fluoxetine (Prozac, Sarafem); fluvoxamine (Luvox); griseofulvin (Fulvicin, Grifulvin, Gris-PEG); lovastatin (Altocor, Mevacor); medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase); medications for thyroid disease; nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate);sertraline (Zoloft); troleandomycin (TAO); verapamil (Calan, Covera, Isoptin, Verelan); and zafirlukast (Accolate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor what herbal products you are taking, especially St. John's wort.

Side Effects

Estrogen injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• breast pain or tenderness
• upset stomach
• vomiting
• weight gain or loss
• dizziness
• nervousness
• depression
• irritability
• changes in sexual desire
• hair loss
• unwanted hair growth
• spotty darkening of the skin on the face
• difficulty wearing contact lenses
• leg cramps
• swelling, redness, burning, itching, or irritation of the vagina
• vaginal discharge

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

• bulging eyes
• pain, swelling, or tenderness in the stomach
• loss of appetite
• weakness
• yellowing of the skin or eyes
• joint pain
• movements that are difficult to control
• rash or blisters
• hives
• itching
• swelling of the eyes, face, tongue, throat, hands, arms, feet, ankles, or lower legs
• hoarseness
• difficulty breathing or swallowing

Estrogen may increase your risk of developing cancer of the ovaries or gallbladder disease that may need to be treated with surgery. Talk to your doctor about the risks of using estrogen injection.

Estrogen may cause growth to slow or stop early in children who receive large doses for a long time. Estrogen injection may also affect the timing and speed of sexual development in children.Your child's doctor will monitor him or her carefully during his or her treatment with estrogen. Talk to your child's doctor about the risks of giving this medication to your child.

Estrogen injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Overdose

In case of overdose, call your local poison control center. If the victim has collapsed or is not breathing, call local emergency services.

Symptoms of overdose may include:

• upset stomach
• vomiting
• vaginal bleeding

Storage

Store Progynon Depot away from light.